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Article

Molecular determinants of immunogenic cell death elicited by radiation therapy

7 Sept 2023

Abstract excerpt

Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell-associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along with the emission of immunostimulatory cytokines and damage-associated molecular patterns (DAMPs) that actively engage immune effector mechanisms (adjuvanticity),...

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PMID: 37679959
DOI: 10.1111/imr.13271

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