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Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models

17 Jul 2014

Abstract excerpt

Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs). Apoptotic cells are capable of inducing tolerance by altering APC maturation. Apoptosis can be induced by extracorporeal photopheresis (ECP). We demonstrate that the use of ECP as a prophylaxis prior to conditioning significantly improves survival (P < .0001)...

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Identifiers

PMID: 25030062
DOI: 10.1182/blood-2014-02-555128

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