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Article

Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.

Thrombosis and haemostasis - 1 Apr 2013

Ding Qiulan, Yang Likui, Hassanian Seyed Mahdi, Rezaie A R

Abstract excerpt

Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While the anticoagulant activity of APC is enhanced by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23389250
DOI: 10.1160/TH12-10-0760
PMCID: PMC3634890

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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