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Article

Gly197Arg mutation in protein C causes recurrent thrombosis in a heterozygous carrier.

Journal of thrombosis and haemostasis : JTH - 1 May 2020

Lu Yeling, Giri Hemant, Villoutreix Bruno O, Ding Qiulan, Wang Xuefeng, Rezaie Alireza R

Abstract excerpt

BACKGROUND: Activated protein C (APC) downregulates thrombin generation by inactivating procoagulant cofactors Va and VIIIa by limited proteolysis. We identified two protein C-deficient patients both of whom carry a heterozygous Gly197 to Arg (G197R) mutation in PROC and experience venous thrombosis. OBJECTIVE: The objective of this study was to determine the molecular basis of the clotting defect in patients...

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Identifiers

PMID: 32078247
DOI: 10.1111/jth.14777
PMCID: PMC7192786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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