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Article

Role of Gly197 in the structure and function of protein C.

Biochimica et biophysica acta. General subjects - 1 Jun 2021

Lu Yeling, Biswas Indranil, Villoutreix Bruno O, Rezaie Alireza R

Abstract excerpt

We previously demonstrated that heterozygous Gly197 to Arg mutation in PROC is associated with venous thrombosis due to the mutation abrogating both zymogenic and enzymatic activities of protein C and activated protein C (APC). In this study, we investigated the role of Gly197 on the structure and function of protein C by replacing it with Ala, Lys and Glu in separate constructs. Characterization of protein C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33722640
DOI: 10.1016/j.bbagen.2021.129892
PMCID: PMC8052293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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