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Article

Supplementary research on K150del variant of activated protein C.

Aging - 25 Apr 2021

Lin Wen-Yi, Tang Liang, Lu Xuan, Hu Yu

Abstract excerpt

Activated protein C (APC) is an anticoagulant with potent cytoprotective and anti-inflammatory effects. K150del, a natural variant of APC, is associated with reduced anticoagulant activity. We performed a comprehensive study to analyze the functional alterations of the K150del mutant. Transcriptome analysis of HEK 293T cells treated with wild and mutant APC revealed differentially expressed genes enriched in...

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Identifiers

PMID: 33896796
DOI: 10.18632/aging.202904
PMCID: PMC8148483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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