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Article

Trp83 is vital to the interaction with phospholipids in γ-carboxyglutamic acid domain of protein C.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2026

Yuan Junwei, Zhou Shijie, Wu Xi, Liu Yu, Xu Guanqun, Ding Qiulan, Wu Wenman, Wang Xuefeng, Dai Jing, Lu Yeling

Abstract excerpt

BACKGROUND: Activated protein C is an important physiological anticoagulant protein. It can downregulate thrombin generation by inactivating coagulation factors Va and VIIIa, thereby exerting an anticoagulant effect. We identified that several families presenting with thrombosis harbored heterozygous mutations at the identical Trp83 residue of PROC, c.247T>C, p.Trp83Arg (W83R) and c.248G>C, and p.Trp83Ser (W83S)....

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Identifiers

PMID: 42276270
DOI: 10.1016/j.jtha.2026.06.006

Genes

PC
PROC

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