Article

High-throughput pipeline for the <i>de novo</i> viral genome assembly and the identification of minority variants from Next-Generation Sequencing of residual diagnostic samples

2015-12-24

Abstract excerpt

<h4>Motivation</h4> The underlying genomic variation of a large number of pathogenic viruses can give rise to drug resistant mutations resulting in treatment failure. Next generation sequencing (NGS) enables the identification of viral quasi-species and the quantification of minority variants in clinical samples; therefore, it can be of direct benefit by detecting drug resistant mutations and devising optimal tre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0af1ea5-b44a-5931-8fc0-e2e1903995bb
DOI: 10.1101/035154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput pipeline for the <i>de novo</i> viral genome assembly and the identification of minority variants from Next-Generation Sequencing of residual diagnostic samplesDOI 10.1101/035154Read

RSV-GenoScan: An automated pipeline for whole-genome human respiratory syncytial virus (RSV) sequence analysis.Semantic proximity Read

Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance with Automated Genotyping and Clinically-important Mutation ReportingSemantic proximity Read

Evaluating the performance of tools used to call minority variants from whole genome short-read dataSemantic proximity Read

A bench-to-data analysis workflow for respiratory syncytial virus whole-genome sequencing with short and long-read approachesSemantic proximity Read

Influenza Classification from Short Reads with VAPOR Facilitates Robust Mapping Pipelines and Zoonotic Strain Detection for Routine Surveillance ApplicationsSemantic proximity Read

INSaFLU: an automated open web-based bioinformatics suite <i>“from-reads”</i> for influenza whole-genome-sequencing-based surveillanceSemantic proximity Read

Viral population analysis and minority-variant detection using short read next-generation sequencing.Semantic proximity Read

SARS-CoV-2 RECoVERY: a multi-platform open-source bioinformatic pipeline for the automatic construction and analysis of SARS-CoV-2 genomes from NGS sequencing dataSemantic proximity Read

Clinical performance evaluation of a tiling amplicon panel for whole genome sequencing of respiratory syncytial virusSemantic proximity Read

ViralFlow: A Versatile Automated Workflow for SARS-CoV-2 Genome Assembly, Lineage Assignment, Mutations and Intrahost Variant Detection.Semantic proximity Read

Tiled PCR amplification-based Whole Genome Sequencing and Phylogenetic Classification Accelerate the Implementation of Respiratory Syncytial Virus Genomic surveillance in Canada as a Pilot StudySemantic proximity Read

ViralFlow: an automated workflow for SARS-CoV-2 genome assembly, lineage assignment, mutations and intrahost variants detectionSemantic proximity Read