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Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

4 Feb 2013

Abstract excerpt

A key step in proliferation of retroviruses is the conversion of their RNA genome to double-stranded DNA, a process catalysed by multifunctional reverse transcriptases (RTs). Dimeric and monomeric RTs have been described, the latter exemplified by the enzyme of Moloney murine leukaemia virus. However, structural information is lacking that describes the substrate binding mechanism for a monomeric RT. We report...

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PMID: 23382176
DOI: 10.1093/nar/gkt053

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