Article

Human RPL7 and DDX21 interact with HTLV-1 Gag and enhance tRNA <sup>Pro</sup> primer annealing to genomic RNA

2025-07-15

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1), an oncogenic retrovirus, uses human tRNA Pro to prime reverse transcription (RT). However, how tRNA Pro is annealed to the primer binding site (PBS), which is embedded in a highly structured hairpin in the genomic RNA (gRNA), remains unclear. We hypothesize that HTLV-1 Gag may have more robust chaperone activity than mature HTLV-1 nucleocapsid (NC), which in contrast...

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Literature Corpus work: 359795c6-7311-5f25-b4af-4def7a3141be
DOI: 10.1101/2025.07.15.664966

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