Article
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
Nucleic acids research - 1 Jan 2007
Németh-Pongrácz Veronika, Barabás Orsolya, Fuxreiter Mónika, Simon István, Pichová Iva, Rumlová Michalea, Zábranská Helena, Svergun Dmitri, Petoukhov Maxim, Harmat Veronika, Klement Eva, Hunyadi-Gulyás Eva, Medzihradszky Katalin F, Kónya Emese, Vértessy Beáta G
Abstract excerpt
The homotrimeric fusion protein nucleocapsid (NC)-dUTPase combines domains that participate in RNA/DNA folding, reverse transcription, and DNA repair in Mason-Pfizer monkey betaretrovirus infected cells. The structural organization of the fusion protein remained obscured by the N- and C-terminal flexible segments of dUTPase and the linker region connecting the two domains that are invisible in electron density...
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