Article
The three-way junction structure of the HIV-1 PBS-segment binds host enzyme important for viral infectivity.
Nucleic acids research - 4 Jun 2021
Song Zhenwei, Gremminger Thomas, Singh Gatikrushna, Cheng Yi, Li Jun, Qiu Liming, Ji Juan, Lange Margaret J, Zuo Xiaobing, Chen Shi-Jie, Zou Xiaoqin, Boris-Lawrie Kathleen, Heng Xiao
Abstract excerpt
HIV-1 reverse transcription initiates at the primer binding site (PBS) in the viral genomic RNA (gRNA). Although the structure of the PBS-segment undergoes substantial rearrangement upon tRNALys3 annealing, the proper folding of the PBS-segment during gRNA packaging is important as it ensures loading of beneficial host factors. DHX9/RNA helicase A (RHA) is recruited to gRNA to enhance the processivity of reverse...
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