Article
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2022
Singh Abhimanyu K, De Wijngaert Brent, Bijnens Marc, Uyttersprot Kris, Nguyen Hoai, Martinez Sergio E, Schols Dominique, Herdewijn Piet, Pannecouque Christophe, Arnold Eddy, Das Kalyan
Abstract excerpt
Structures trapping a variety of functional and conformational states of HIV-1 reverse transcriptase (RT) have been determined by X-ray crystallography. These structures have played important roles in explaining the mechanisms of catalysis, inhibition, and drug resistance and in driving drug design. However, structures of several desired complexes of RT could not be obtained even after many crystallization or...
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