Article
Oligomeric structures of poliovirus polymerase are important for function.
The EMBO journal - 1 Mar 2001
Hobson S D, Rosenblum E S, Richards O C, Richmond K, Kirkegaard K, Schultz S C
Abstract excerpt
Central to the replication of poliovirus and other positive-strand RNA viruses is the virally encoded RNA-dependent RNA polymerase. Previous biochemical studies have suggested that direct polymerase- polymerase interactions might be important for polymerase function, and the structure of poliovirus polymerase has revealed two regions of extensive polymerase-polymerase interaction. To explore potential functional...
Topics
- Amino Acid Substitution
- Binding Sites
- DNA
- Disulfides
- HIV Reverse Transcriptase
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Poliovirus
- Protein Binding
- Protein Structure, Quaternary
- RNA, Viral
- RNA-Binding Proteins
- RNA-Dependent RNA Polymerase
- Viral Plaque Assay
- Virus Replication
- Zinc