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Article

Sequential structures provide insights into the fidelity of RNA replication

22 May 2007

Abstract excerpt

RNA virus replication is an error-prone event caused by the low fidelity of viral RNA-dependent RNA polymerases. Replication fidelity can be decreased further by the use of mutagenic ribonucleoside analogs to a point where viral genetic information can no longer be maintained. For foot-and-mouth disease virus, the antiviral analogs ribavirin and 5-fluorouracil have been shown to be mutagenic, contributing to...

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PMID: 17517631
DOI: 10.1073/pnas.0700518104

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