Article
Whole-genome sequencing of the world's oldest people.
PloS one - 1 Jan 2014
Gierman Hinco J, Fortney Kristen, Roach Jared C, Coles Natalie S, Li Hong, Glusman Gustavo, Markov Glenn J, Smith Justin D, Hood Leroy, Coles L Stephen, Kim Stuart K
Abstract excerpt
Supercentenarians (110 years or older) are the world's oldest people. Seventy four are alive worldwide, with twenty two in the United States. We performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity. We found no significant evidence of enrichment for a single rare protein-altering variant or for a gene harboring different rare protein altering...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.