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Article

Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations.

Technology in cancer research & treatment - 1 Jan 2000

Balabanski Lubomir, Serbezov Dimitar, Nikolova Dragomira, Antonova Olga, Nesheva Desislava, Hammoudeh Zora, Vazharova Radoslava, Karachanak-Yankova Sena, Staneva Rada, Mihaylova Marta, Damyanova Vera, Hadjidekova Savina, Toncheva Draga

Abstract excerpt

OBJECTIVES: The aim of the present study was to evaluate the clinical relevance of mutations in tumor suppressor genes using whole-exome sequencing data from centenarians and young healthy individuals. METHODS: Two pools, one of centenarians and one of young individuals, were constructed and whole-exome sequencing was performed. We examined the whole-exome sequencing data of Bulgarian individuals for carriership...

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Age Factors
Aged, 80 and over
Exome
Exome Sequencing
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

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Open in PubMed Open full text

Identifiers

PMID: 32233832
DOI: 10.1177/1533033820911082
PMCID: PMC7132786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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