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Article

Macrophage phenotypes in the collagen-induced foreign body reaction in rats.

Acta biomaterialia - 1 May 2013

van Putten Sander M, Ploeger Diana T A, Popa Eliane R, Bank Ruud A

Abstract excerpt

Implantation of biomaterials into the body elicits a material-dependent inflammatory response called the foreign body reaction (FBR). Macrophages play a pivotal role in the FBR by orchestrating the pro-inflammatory microenvironment around the biomaterials by secreting cytokines, chemokines and growth factors. When the biomaterial is porous or degradable, macrophages can migrate into the material and continue the...

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PMID: 23376130
DOI: 10.1016/j.actbio.2013.01.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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