Article
Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component.
Biomaterials - 1 Mar 2009
Brown Bryan N, Valentin Jolene E, Stewart-Akers Ann M, McCabe George P, Badylak Stephen F
Abstract excerpt
Recently, macrophages have been characterized as having an M1 or M2 phenotype based on receptor expression, cytokine and effector molecule production, and function. The effects of macrophage phenotype upon tissue remodeling following the implantation of a biomaterial are largely unknown. The objectives of this study were to determine the effects of a cellular component within an implanted extracellular matrix...
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