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Article

Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels.

Journal of biomaterials science. Polymer edition - 1 Jan 2016

Yu Tony, Wang Wenbo, Nassiri Sina, Kwan Thomas, Dang Chau, Liu Wei, Spiller Kara L

Abstract excerpt

Currently, it is not well understood how changes in biomaterial properties affect the foreign body response (FBR) or macrophage behavior. Because failed attempts at biomaterial degradation by macrophages have been linked to frustrated phagocytosis, a defining feature of the FBR, we hypothesized that increased hydrogel crosslinking density (and decreased degradability) would exacerbate the FBR. Gelatin hydrogels...

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Identifiers

PMID: 26902292
DOI: 10.1080/09205063.2016.1155881
PMCID: PMC4879875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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