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Article

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Gimbrone Michael A, García-Cardeña Guillermo

Abstract excerpt

The localization of atherosclerotic lesion formation to regions of disturbed blood flow associated with certain arterial geometries, in humans and experimental animals, suggests an important role for hemodynamic forces in the pathobiology of atherosclerosis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Share to Mechanotransduction, Cellular

Share to Plaque, Atherosclerotic

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Source

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Identifiers

PMID: 22818581
DOI: 10.1016/j.carpath.2012.06.006
PMCID: PMC4564111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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