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Article

Biomechanical factors and macrophages in plaque stability.

Cardiovascular research - 15 Jul 2013

Seneviratne Anusha, Hulsmans Maarten, Holvoet Paul, Monaco Claudia

Abstract excerpt

Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis is dependent upon complex patterns of blood flow. Slow-flowing blood imposing low shear stress on the arterial wall up-regulates inflammatory...

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Share to Biomechanical Phenomena
Share to Hemodynamics
Share to Macrophage Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Plaque, Atherosclerotic

Share to Regional Blood Flow

Share to Rupture, Spontaneous

Share to Stress, Mechanical

Source

Identifiers

PMID: 23687352
DOI: 10.1093/cvr/cvt097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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