Article
A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.
Human molecular genetics - 1 May 2013
Lane Jérôme, McLaren Paul J, Dorrell Lucy, Shianna Kevin V, Stemke Amanda, Pelak Kimberly, Moore Stephen, Oldenburg Johannes, Alvarez-Roman Maria Teresa, Angelillo-Scherrer Anne, Boehlen Francoise, Bolton-Maggs Paula H B, Brand Brigit, Brown Deborah, Chiang Elaine, Cid-Haro Ana Rosa, Clotet Bonaventura, Collins Peter, Colombo Sara, Dalmau Judith, Fogarty Patrick, Giangrande Paul, Gringeri Alessandro, Iyer Rathi, Katsarou Olga, Kempton Christine, Kuriakose Philip, Lin Judith, Makris Mike, Manco-Johnson Marilyn, Tsakiris Dimitrios A, Martinez-Picado Javier, Mauser-Bunschoten Evelien, Neff Anne, Oka Shinichi, Oyesiku Lara, Parra Rafael, Peter-Salonen Kristiina, Powell Jerry, Recht Michael, Shapiro Amy, Stine Kimo, Talks Katherine, Telenti Amalio, Wilde Jonathan, Yee Thynn Thynn, Wolinsky Steven M, Martinson Jeremy, Hussain Shehnaz K, Bream Jay H, Jacobson Lisa P, Carrington Mary, Goedert James J, Haynes Barton F, McMichael Andrew J, Goldstein David B, Fellay Jacques
Abstract excerpt
Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated factor VIII infusions. Individuals with hemophilia A and a documented history of factor VIII infusions before the introduction of viral inactivation procedures...
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