Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.

Blood - 21 Feb 2013

Astermark Jan, Donfield Sharyne M, Gomperts Edward D, Schwarz John, Menius Erika D, Pavlova Anna, Oldenburg Johannes, Kessing Bailey, DiMichele Donna M, Shapiro Amy D, Winkler Cheryl A, Berntorp Erik

Abstract excerpt

Studies of determinants of development of inhibitory Abs to factor VIII in people with hemophilia A indicate a complex process involving multiple factors. The Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort was formed to extend our understanding of the genetic background of risk. The study group contains 833 subjects from 3 independent cohorts: brother pairs and singletons with and without a history of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Factor VIII

Share to Hemophilia A

Share to Multifactorial Inheritance

Share to Siblings

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 23223434
DOI: 10.1182/blood-2012-06-434803
PMCID: PMC3578958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.PMID 23223434Read ↗

A scan of pleiotropic immune mediated disease genes identifies novel determinants of baseline FVIII inhibitor status in hemophilia A.Semantic proximity Read ↗

A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-ASemantic proximity Read ↗

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research RepositorySemantic proximity Read ↗

HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdatasetSemantic proximity Read ↗

Prevention and prediction of inhibitor risk.Semantic proximity Read ↗

Inhibitor development in hemophiliacs: the roles of genetic versus environmental factors.Semantic proximity Read ↗

A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A.Semantic proximity Read ↗

Genetics and Epigenetics in Acquired Hemophilia A: From Bench to BedsideSemantic proximity Read ↗

Human leukocyte antigen alleles associated with inhibitor development in severe hemophilia A: analysis of the "My Life, Our Future" hemophilia A cohort.Semantic proximity Read ↗

Prevention of inhibitor development in hemophilia A in 2016. A glimpse into the future?Semantic proximity Read ↗

The role of genetics in inhibitor formation.Semantic proximity Read ↗

Assessing risk factors: prevention of inhibitors in haemophilia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.