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Article

Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.

Developmental cell - 28 Jan 2013

Park Laura, Thomason Peter A, Zech Tobias, King Jason S, Veltman Douwe M, Carnell Michael, Ura Seiji, Machesky Laura M, Insall Robert H

Abstract excerpt

WASH causes actin to polymerize on vesicles involved in retrograde traffic and exocytosis. It is found within a regulatory complex, but the physiological roles of the other four members are unknown. Here we present genetic analysis of the subunits' individual functions in Dictyostelium. Mutants in each subunit are completely blocked in exocytosis. All subunits except FAM21 are required to drive actin assembly on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23369714
DOI: 10.1016/j.devcel.2012.12.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.PMID 23369714Read ↗

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