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Article

Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole.

Molecular biology of the cell - 1 Apr 2012

Essid Miriam, Gopaldass Navin, Yoshida Kunito, Merrifield Christien, Soldati Thierry

Abstract excerpt

Water expulsion by the contractile vacuole (CV) in Dictyostelium is carried out by a giant kiss-and-run focal exocytic event during which the two membranes are only transiently connected but do not completely merge. We present a molecular dissection of the GTPase Rab8a and the exocyst complex in tethering of the contractile vacuole to the plasma membrane, fusion, and final detachment. Right before discharge, the...

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Identifiers

PMID: 22323285
DOI: 10.1091/mbc.E11-06-0576
PMCID: PMC3315810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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