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A statistical method for the detection of variants from next-generation resequencing of DNA pools.

Bioinformatics (Oxford, England) - 15 Jun 2010

Bansal Vikas

Abstract excerpt

MOTIVATION: Next-generation sequencing technologies have enabled the sequencing of several human genomes in their entirety. However, the routine resequencing of complete genomes remains infeasible. The massive capacity of next-generation sequencers can be harnessed for sequencing specific genomic regions in hundreds to thousands of individuals. Sequencing-based association studies are currently limited by the low...

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Algorithms
Base Sequence
Data Interpretation, Statistical
Genetic Variation
Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

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PMID: 20529923
DOI: 10.1093/bioinformatics/btq214
PMCID: PMC2881398

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