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Article

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

The Journal of biological chemistry - 4 Mar 2016

Loeven Markus A, Rops Angelique L, Lehtinen Markus J, van Kuppevelt Toin H, Daha Mohamed R, Smith Richard J, Bakker Marinka, Berden Jo H, Rabelink Ton J, Jokiranta T Sakari, van der Vlag Johan

Abstract excerpt

Complement factor H (FH) inhibits complement activation and interacts with glomerular endothelium via its complement control protein domains 19 and 20, which also recognize heparan sulfate (HS). Abnormalities in FH are associated with the renal diseases atypical hemolytic uremic syndrome and dense deposit disease and the ocular disease age-related macular degeneration. Although FH systemically controls complement...

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Identifiers

PMID: 26728463
DOI: 10.1074/jbc.M115.702506
PMCID: PMC4777835

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TNF

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Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.PMID 26728463Read ↗

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