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Article

Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.

The Journal of biological chemistry - 1 Mar 2022

Minogue Peter J, Tong Jun-Jie, Wichmann Kelly, Mysliwiec Hubert, Ebihara Lisa, Beyer Eric C, Berthoud Viviana M

Abstract excerpt

Many human connexin50 (Cx50) mutants have been linked to cataracts including two carboxyl terminus serine mutants that are known phosphorylation sites in the lens (Cx50S258F and Cx50S259Y). To examine the behavior of these mutants and the role of phosphorylation at these positions, we stably transfected HeLa cells with cataract-linked and phosphorylation-mimicking (Cx50S258D and Cx50S259D) Cx50 mutants. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35120923
DOI: 10.1016/j.jbc.2022.101673
PMCID: PMC8927986

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