Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Viral resistance burden and APOBEC editing correlate with virological response in heavily treatment-experienced people living with multi-drug resistant HIV.

International journal of antimicrobial agents - 1 Jan 2022

Armenia Daniele, Santoro Maria Mercedes, Bellocchi Maria Concetta, Carioti Luca, Galli Laura, Galli Andrea, Scutari Rossana, Salsi Eleonora, Mussini Cristina, Sterrantino Gaetana, Calza Leonardo, Rossetti Barbara, Zazzi Maurizio, Castagna Antonella

Abstract excerpt

BACKGROUND: The impact of drug resistance mutational load and APOBEC editing in heavily treatment-experienced (HTE) people living with multidrug-resistant HIV has not been investigated. MATERIAL AND METHODS: This study explored the HIV-DNA and HIV-RNA mutational load of drug resistance and APOBEC-related mutations through next-generation sequencing (NGS, Illumina MiSeq) in 20 failing HTE participants enrolled in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to APOBEC-1 Deaminase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Gene Editing

Share to HIV Infections

Share to Sequence Analysis, RNA

Share to Viral Load

Source

Identifiers

PMID: 34871747
DOI: 10.1016/j.ijantimicag.2021.106492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Viral resistance burden and APOBEC editing correlate with virological response in heavily treatment-experienced people living with multi-drug resistant HIV.PMID 34871747Read ↗

Use of next-generation sequencing on HIV-1 DNA to assess archived resistance in highly treatment-experienced people with multidrug-resistant HIV under virological control: data from the PRESTIGIO Registry.Semantic proximity Read ↗

Evaluation of HIV-1 DNA resistance evolution in highly treatment-experienced and multi-resistant individuals under suppressive antiretroviral therapy: a longitudinal study from the PRESTIGIO Registry.Semantic proximity Read ↗

Next-generation sequencing reveals major and minority HIV-1 drug resistance mutations in treatment-experienced individuals with virological failure.Semantic proximity Read ↗

Current levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response.Semantic proximity Read ↗

Temporal trend of drug-resistance and APOBEC editing in PBMC genotypic resistance tests from HIV-1 infected virologically suppressed individuals.Semantic proximity Read ↗

HIV-1 genotypic drug resistance testing: digging deep, reaching wide?Semantic proximity Read ↗

Next-generation sequencing (NGS) reveals low-abundance HIV-1 drug resistance mutations among patients experiencing virological failure at the time of therapy switching in UgandaSemantic proximity Read ↗

An observational study of high- and low-abundance anti-retroviral resistance mutations among treatment-naïve people living with HIV in New Zealand between 2012 and 2017.Semantic proximity Read ↗

Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study.Semantic proximity Read ↗

Brief Report: Comparative Analysis of Pre-existing HIV Drug Resistance Mutations in Proviral DNA Using Next-Generation Sequencing and Routine HIV RNA Genotyping.Semantic proximity Read ↗

HIV MDR is still a relevant issue despite its dramatic drop over the years.Semantic proximity Read ↗

Primary HIV-1 Drug Resistant Minority Variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.