Article
Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding.
The EMBO journal - 20 Feb 2013
Keren-Kaplan Tal, Attali Ilan, Estrin Michael, Kuo Lillian S, Farkash Efrat, Jerabek-Willemsen Moran, Blutraich Noa, Artzi Shay, Peri Aviyah, Freed Eric O, Wolfson Haim J, Prag Gali
Abstract excerpt
The ubiquitylation signal promotes trafficking of endogenous and retroviral transmembrane proteins. The signal is decoded by a large set of ubiquitin (Ub) receptors that tether Ub-binding domains (UBDs) to the trafficking machinery. We developed a structure-based procedure to scan the protein data bank for hidden UBDs. The screen retrieved many of the known UBDs. Intriguingly, new potential UBDs were identified,...
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