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Article

Activation of the retroviral budding factor ALIX.

Journal of virology - 1 Sept 2011

Zhai Qianting, Landesman Michael B, Chung Hyo-Young, Dierkers Adam, Jeffries Cy M, Trewhella Jill, Hill Christopher P, Sundquist Wesley I

Abstract excerpt

The cellular ALIX protein functions within the ESCRT pathway to facilitate intralumenal endosomal vesicle formation, the abscission stage of cytokinesis, and enveloped virus budding. Here, we report that the C-terminal proline-rich region (PRR) of ALIX folds back against the upstream domains and auto-inhibits V domain binding to viral late domains. Mutations designed to destabilize the closed conformation of the...

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Identifiers

PMID: 21715492
DOI: 10.1128/JVI.02653-10
PMCID: PMC3165844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activation of the retroviral budding factor ALIX.PMID 21715492Read ↗

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.Semantic proximity Read ↗

A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.Semantic proximity Read ↗

ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus EgressSemantic proximity Read ↗

Abrogating ALIX interactions results in stuttering of the ESCRT machinerySemantic proximity Read ↗

AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus BuddingSemantic proximity Read ↗

Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding.Semantic proximity Read ↗

ALIX-CHMP4 interactions in the human ESCRT pathway.Semantic proximity Read ↗

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteinsSemantic proximity Read ↗

ALIX/AIP1 Is Required for NP Incorporation into Mopeia Virus Z-Induced Virus-Like ParticlesSemantic proximity Read ↗

Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.Semantic proximity Read ↗

Refined study of the interaction between HIV-1 p6 late domain and ALIX.Semantic proximity Read ↗

Herpes Simplex Virus Type 1 Production Requires a Functional ESCRT-III Complex but Is Independent of TSG101 and ALIX ExpressionSemantic proximity Read ↗

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