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Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication

29 Feb 2024

Abstract excerpt

Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination of VP35 promotes virus replication by regulating interactions with the polymerase complex. In addition, VP35 can...

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PMID: 38422166
DOI: 10.1371/journal.pbio.3002544

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