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Article

A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.

Structure (London, England : 1993) - 10 Jun 2009

Pires Ricardo, Hartlieb Bettina, Signor Luca, Schoehn Guy, Lata Suman, Roessle Manfred, Moriscot Christine, Popov Sergei, Hinz Andreas, Jamin Marc, Boyer Veronique, Sadoul Remy, Forest Eric, Svergun Dmitri I, Göttlinger Heinrich G, Weissenhorn Winfried

Abstract excerpt

ALIX recruits ESCRT-III CHMP4 and is involved in membrane remodeling during endosomal receptor sorting, budding of some enveloped viruses, and cytokinesis. We show that ALIX dimerizes via the middle domain (ALIX(-V)) in solution. Structural modeling based on small angle X-ray scattering (SAXS) da...

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Identifiers

PMID: 19523902
DOI: 10.1016/j.str.2009.04.007
PMCID: PMC2699623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19523902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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