Article
The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1.
Genes and immunity - 1 Dec 2005
Reddy M V Prasad Linga, Johansson M, Sturfelt G, Jönsen A, Gunnarsson I, Svenungsson E, Rantapää-Dahlqvist S, Alarcón-Riquelme M E
Abstract excerpt
The gene PTPN22 is located on chromosome 1p13 and encodes a protein tyrosine phosphatase called the lymphoid-specific phosphatase (Lyp). Lyp is expressed in lymphocytes, where it physically associates through its proline-rich motif (called P1) with the SH3 domain of the protein tyrosine kinase Csk, an important suppressor of the Src family of kinases Lck and Fyn, which mediate TCR signaling. Therefore, it is said...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.