Article
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine - 11 Feb 2013
Lobry Camille, Ntziachristos Panagiotis, Ndiaye-Lobry Delphine, Oh Philmo, Cimmino Luisa, Zhu Nan, Araldi Elisa, Hu Wenhuo, Freund Jacquelyn, Abdel-Wahab Omar, Ibrahim Sherif, Skokos Dimitris, Armstrong Scott A, Levine Ross L, Park Christopher Y, Aifantis Iannis
Abstract excerpt
Notch signaling pathway activation is known to contribute to the pathogenesis of a spectrum of human malignancies, including T cell leukemia. However, recent studies have implicated the Notch pathway as a tumor suppressor in myeloproliferative neoplasms and several solid tumors. Here we report a novel tumor suppressor role for Notch signaling in acute myeloid leukemia (AML) and demonstrate that Notch pathway...
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