Article
Polymorphism in IgG Fc receptor gene FCGR3A and response to infliximab in Crohn's disease: a subanalysis of the ACCENT I study.
Pharmacogenetics and genomics - 1 Dec 2006
Louis Edouard J, Watier Hervé E, Schreiber Stefan, Hampe Jochen, Taillard François, Olson Allan, Thorne Nicole, Zhang Hongyan, Colombel Jean-Frédéric
Abstract excerpt
Recently, it has been shown that FCGR3A-158 gene polymorphism is associated with biological and possibly clinical response to infliximab in Crohn's disease. We further assessed this association in a subset of 344 patients from the large and well-defined cohort of 573 patients with Crohn's disease from the ACCENT I study. No association could be observed between FCGR3A-158 gene polymorphism and the clinical...
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