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Article

Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease.

Alimentary pharmacology & therapeutics - 1 May 2008

Matsukura H, Ikeda S, Yoshimura N, Takazoe M, Muramatsu M

Abstract excerpt

BACKGROUND: Tumour necrosis factor alpha is the key inflammatory cytokine involved in the pathogenesis of Crohn's disease. Infliximab, a chimaeric monoclonal antibody of tumour necrosis factor-alpha is successfully used for the treatment of Crohn's disease, although the response to infliximab therapy differs among patients. The genetic background of the individual may partially explain the differences of the...

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Source

Identifiers

PMID: 18248655
DOI: 10.1111/j.1365-2036.2008.03630.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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