Multiple regulatory elements determine adrenocortical expression of steroid 21-hydroxylase.

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Article

Multiple regulatory elements determine adrenocortical expression of steroid 21-hydroxylase.

The Journal of biological chemistry - 15 May 1990

Rice D A, Kronenberg M S, Mouw A R, Aitken L D, Franklin A, Schimmer B P, Parker K L

Abstract excerpt

Steroid 21-hydroxylase (21-OHase) is specifically expressed at high levels in the adrenal cortex, where it is required for the synthesis of mineralocorticoids and glucocorticoids. In this study, we have investigated the regulatory elements in the 21-OHase promoter region which contribute to the expression of this gene in Y1 adrenocortical cells. Eight potential regulatory elements in the 5'-flanking region of the...

Topics

Adrenal Cortex
Adrenal Cortex Neoplasms
Adrenal Gland Neoplasms
Animals
Base Sequence
Cell Nucleus
Deoxyribonuclease I
Gene Expression Regulation
HeLa Cells
Humans
Leydig Cell Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Pheochromocytoma

Promoter Regions, Genetic

Regulatory Sequences, Nucleic Acid

Steroid 21-Hydroxylase

Source

Open in PubMed

Identifiers

PMID: 2335516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2335516-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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