Article
Steroid 21-hydroxylase expression and activity in human lymphocytes.
Molecular and cellular endocrinology - 14 Mar 1997
Zhou Z, Agarwal V R, Dixit N, White P, Speiser P W
Abstract excerpt
Steroid 21-hydroxylase encoded by CYP21 is expressed in adrenal cortex. Mutations in CYP21 cause potentially lethal congenital adrenal hyperplasia (CAH). Earlier observations suggested alternative sources of 21-hydroxylase activity, although its genetic source remains unclear. We found a novel source of CYP21 expression in normal human cultured B lymphocytes. The quantity of 21-hydroxylase transcript was reduced...
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