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Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation

5 Jul 2017

Abstract excerpt

The Retinoblastoma (RB) tumor suppressor regulates G1/S transition during cell cycle progression by modulating the activity of E2F transcription factors. The RB pathway plays a central role in the suppression of most cancers, and RB mutation was initially discovered by virtue of its role in tumor initiation. However, as cancer genome sequencing has evolved to profile more advanced and treatment‐resistant cancers,...

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PMID: 28865172
DOI: 10.1111/cas.13312

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