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PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature

7 Jun 2018

Abstract excerpt

PRDM16 is a transcriptional coregulator involved in translocations in acute myeloblastic leukemia (AML), myelodysplastic syndromes, and T acute lymphoblastic leukemia that is highly expressed in and required for the maintenance of hematopoietic stem cells (HSCs), and can be aberrantly expressed in AML. Prdm16 is expressed as full-length (fPrdm16) and short (sPrdm16) isoforms, the latter lacking the N-terminal PR...

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PMID: 29878897
DOI: 10.1172/jci99862

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