Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrinsically disordered regions of p53 family are highly diversified in evolution.

Biochimica et biophysica acta - 1 Apr 2013

Xue Bin, Brown Celeste J, Dunker A Keith, Uversky Vladimir N

Abstract excerpt

Proteins of the p53 family are expressed in vertebrates and in some invertebrate species. The main function of these proteins is to control and regulate cell cycle in response to various cellular signals, and therefore to control the organism's development. The regulatory functions of the p53 family members originate mostly from their highly-conserved and well-structured DNA-binding domains. Many human diseases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Conserved Sequence
Share to Databases, Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Mutation, Missense

Share to Protein Conformation

Share to Protein Structure, Tertiary

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 23352836
DOI: 10.1016/j.bbapap.2013.01.012
PMCID: PMC3905691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrinsically disordered regions of p53 family are highly diversified in evolution.PMID 23352836Read ↗

Mutational Hotspots and Conserved Domains in P53 Tumour Suppressor ProteinSemantic proximity Read ↗

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations.Semantic proximity Read ↗

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read ↗

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.Semantic proximity Read ↗

Evolutionary forces on different flavors of intrinsic disorder in the human proteomeSemantic proximity Read ↗

Phenotypical mapping of TP53 unique missense mutations spectrum in human cancersSemantic proximity Read ↗

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.Semantic proximity Read ↗

Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.Semantic proximity Read ↗

Evolutionary Conservation and Functional Constraint of TP53 Mutation Hotspots Across Mammalian SpeciesSemantic proximity Read ↗

The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in LongevitySemantic proximity Read ↗

Dipeptide analysis of p53 mutations and evolution of p53 family proteins.Semantic proximity Read ↗

The changes in the p53 protein across the animal kingdom pointing to its involvement in longevitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.