Establishment of two new multi-drug resistant variants of the human tumor line Hep-2.

doi:10.1007/BF02443804

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Article

Establishment of two new multi-drug resistant variants of the human tumor line Hep-2.

Cell biology and toxicology - 1 Jul 1990

Redmond A, Law E, Gilvarry U, Clynes M

Abstract excerpt

Two multi-drug resistant variants of the human carcinoma line Hep-2 have been selected by adaptation to progressively increasing concentrations of adriamycin. In comparison to the wild-type Hep-2 cells, the variant lines both showed approximately 100-fold resistance to adriamycin, 10 to 20-fold r...

Topics

Antineoplastic Agents
Drug Resistance
Humans
Karyotyping
Phenotype
Trypsin
Tumor Cells, Cultured

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