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Article

BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis.

Diseases of the colon and rectum - 1 Feb 2012

Kalady Matthew F, Dejulius Kathryn L, Sanchez Julian A, Jarrar Awad, Liu Xiuli, Manilich Elena, Skacel Marek, Church James M

Abstract excerpt

BACKGROUND: Colorectal cancer is a heterogeneous disease with multiple underlying genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer. However, there is a paucity of information about BRAF mutant colorectal tumors. OBJECTIVE: This study defines the clinical characteristics and oncologic...

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Identifiers

PMID: 22228154
DOI: 10.1097/DCR.0b013e31823c08b3

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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