Article
BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis.
Diseases of the colon and rectum - 1 Feb 2012
Kalady Matthew F, Dejulius Kathryn L, Sanchez Julian A, Jarrar Awad, Liu Xiuli, Manilich Elena, Skacel Marek, Church James M
Abstract excerpt
BACKGROUND: Colorectal cancer is a heterogeneous disease with multiple underlying genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer. However, there is a paucity of information about BRAF mutant colorectal tumors. OBJECTIVE: This study defines the clinical characteristics and oncologic...
Topics
- Adenocarcinoma
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- DNA Mutational Analysis
- Female
- Humans
- Kaplan-Meier Estimate