Article
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013
Tomasetti Cristian, Vogelstein Bert, Parmigiani Giovanni
Abstract excerpt
Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental issue, we formulated a mathematical model for the evolution of somatic muta...
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