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Article

Development of a novel codon-specific polymerase chain reaction for the detection of CXCR4-utilizing HIV type 1 subtype B.

AIDS research and human retroviruses - 1 May 2013

McLaughlin Sherry, Swenson Luke C, Hu Shengbo, Hughes Paul, Harrigan P Richard, Coombs Robert W, Frenkel Lisa M

Abstract excerpt

Insight concerning the switch in HIV-1 coreceptor use will lead to a better understanding of HIV-1 pathogenesis and host-virus dynamics. Predicting CXCR4 utilization by analyzing HIV-1 envelope consensus sequences is highly specific, but minority variants in the viral population are often missed resulting in low sensitivity. Commercial phenotypic assays are costly, and the development of sensitive in-house...

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Identifiers

PMID: 23343425
DOI: 10.1089/aid.2012.0024
PMCID: PMC3636599

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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