Article
[TGF-Beta1-915G/C and TNF-alpha-308G/A polymorphisms in children with asthma].
Tuberkuloz ve toraks - 1 Jan 2009
Aytekin Caner, Doğu Figen, Ikincioğullari Aydan, Eğin Yonca, Yüksek Mutlu, Bozdoğan Günseli, Akar Nejat, Babacan Emel
Abstract excerpt
TGF-Beta1 is a pro and antiinflammatory cytokine and plays an important role in airway remodelling in asthma. TNF-alpha is a proinflammatory cytokine that involved in the pathogenesis of asthma. Cytokine production is under genetic control, and certain single nucleotide polymorphisms (SNPs), which lead to allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro. In some...
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