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Article

<i>De novo</i> protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

18 Feb 2003

Abstract excerpt

Activation-induced cytidine deaminase (AID) is required for class-switch recombination (CSR), somatic hypermutation, and gene conversion of Ig genes. Although AID has sequence similarity to an RNA-editing enzyme Apobec-1, how AID functions in CSR and somatic hypermutation is unknown. Because involvement of RNA-editing but not DNA-editing in CSR requires de novo protein synthesis after AID expression, we examined...

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Identifiers

PMID: 12591955
DOI: 10.1073/pnas.0437710100

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