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Article

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.

PLoS computational biology - 1 May 2006

Beroukhim Rameen, Lin Ming, Park Yuhyun, Hao Ke, Zhao Xiaojun, Garraway Levi A, Fox Edward A, Hochberg Ephraim P, Mellinghoff Ingo K, Hofer Matthias D, Descazeaud Aurelien, Rubin Mark A, Meyerson Matthew, Wong Wing Hung, Sellers William R, Li Cheng

Abstract excerpt

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the no...

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Identifiers

PMID: 16699594
DOI: 10.1371/journal.pcbi.0020041
PMCID: PMC1458964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16699594-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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